InnateDB Protein
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IDBP-590146.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HELB
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Protein Name
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helicase (DNA) B
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000443287
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InnateDB Gene
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IDBG-45661 (HELB)
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Protein Structure
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Function |
Unwinds duplex DNA with 5'-3' polarity. Has single- strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress. {ECO:0000269PubMed:12181327, ECO:0000269PubMed:22194613}.
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Subcellular Localization |
Note=Preferentially during S phase, recruited to chromatin following DNA damage induced by UV irradiation, or camptothecin or hydroxyurea treatment.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis and thymus and weakly in liver, spleen, kidney and brain. {ECO:0000269PubMed:12181327}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005524
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ATP binding
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GO:0017116
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single-stranded DNA-dependent ATP-dependent DNA helicase activity
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GO:0043141
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ATP-dependent 5'-3' DNA helicase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NG08
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PhosphoSite |
PhosphoSite-Q8NG08
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
92797
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UniGene |
Hs.505941
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RefSeq |
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HUGO |
HGNC:17196
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OMIM |
614539
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CCDS |
CCDS8976
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HPRD |
09979
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IMGT |
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EMBL |
AF319995
AK024464
AK290894
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GenPept |
AAM73554
BAB15754
BAF83583
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