InnateDB Protein
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IDBP-590317.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DIO1
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Protein Name
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deiodinase, iodothyronine, type I
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Synonyms
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5DI; TXDI1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000434758
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InnateDB Gene
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IDBG-98807 (DIO1)
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Protein Structure
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Function |
Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0004800
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thyroxine 5'-deiodinase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000643
Iodothyronine deiodinase
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PFAM |
PF00837
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PRINTS |
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PIRSF |
PIRSF001330
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P49895
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PhosphoSite |
PhosphoSite-P49895
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1733
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UniGene |
Hs.251415
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RefSeq |
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HUGO |
HGNC:2883
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OMIM |
147892
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CCDS |
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HPRD |
01002
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IMGT |
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EMBL |
AL031427
AY560374
AY560375
AY560376
AY560377
AY560378
AY560379
AY560380
AY560381
AY560382
AY560383
BC017955
BC107170
BC107171
S48220
S79349
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GenPept |
AAB23670
AAB35380
AAH17955
AAI07171
AAI07172
AAT02480
AAT02481
AAT02482
AAT02483
AAT02484
AAT02485
AAT02486
AAT02487
AAT02488
AAT02489
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