Version 5.4
Homo sapiens Protein: MAF1
Summary
InnateDB Protein IDBP-590492.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAF1
Protein Name MAF1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000436720
InnateDB Gene IDBG-40110 (MAF1)
Protein Structure
UniProt Annotation
Function Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. {ECO:0000269PubMed:20233713, ECO:0000269PubMed:20516213, ECO:0000269PubMed:20543138}.
Subcellular Localization Nucleus. Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001030 RNA polymerase III type 1 promoter DNA binding
GO:0001031 RNA polymerase III type 2 promoter DNA binding
GO:0001032 RNA polymerase III type 3 promoter DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0016480 negative regulation of transcription from RNA polymerase III promoter
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR015257 Repressor of RNA polymerase III transcription Maf1
PFAM PF09174
PRINTS
PIRSF PIRSF037240
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H063
PhosphoSite PhosphoSite-Q9H063
TrEMBL E9PJ05
UniProt Splice Variant
Entrez Gene 84232
UniGene Hs.19673
RefSeq
HUGO HGNC:24966
OMIM 610210
CCDS CCDS6416
HPRD 14345
IMGT
EMBL AC104592 AL136937 BC014082 BC018714 BC031273 CH471162 CR533463
GenPept AAH14082 AAH18714 AAH31273 CAB66871 CAG38494 EAW82158 EAW82159

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca