Version 5.4
Homo sapiens Protein: SYBU
Summary
InnateDB Protein IDBP-590569.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYBU
Protein Name syntabulin (syntaxin-interacting)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000436266
InnateDB Gene IDBG-32815 (SYBU)
Protein Structure
UniProt Annotation
Function Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250}.
Subcellular Localization Isoform 1: Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Note=Colocalizes with syntaxin vesicles along microtubules in neuronal processes.Isoform 3: Golgi apparatus membrane; Single- pass membrane protein.Isoform 4: Golgi apparatus membrane; Single- pass membrane protein.Isoform 5: Golgi apparatus membrane; Single- pass membrane protein.
Disease Associations
Tissue Specificity Isoform 3, isoform 4 and isoform 5 are expressed in HeLa cell line (at protein level). Isoform 3 is expressed in fetal and adult brain. Isoform 4 is expressed in numerous fetal tissues (brain, kidney, liver, lung, and thymus) and in adult brain, kidney, liver, lung, pancreas, colon, prostate, small intestine, testis and thymus. Isoform 5 is expressed in fetal brain, brain and small intestine. {ECO:0000269PubMed:15656992}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017075 syntaxin-1 binding
GO:0019894 kinesin binding
Biological Process
Cellular Component
GO:0000139 Golgi membrane
GO:0005856 cytoskeleton
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NX95
PhosphoSite PhosphoSite-Q9NX95
TrEMBL E9PRT7
UniProt Splice Variant
Entrez Gene 55638
UniGene Hs.390738
RefSeq XP_005251056
HUGO HGNC:26011
OMIM 611568
CCDS
HPRD 07902
IMGT
EMBL AB040905 AB195676 AB195677 AB195678 AB195679 AC079061 AK000373 AK090559 AK091374 AK096558 AK290469 AL713645 AL834406 AY705385 BC012082 CH471060
GenPept AAH12082 AAU93914 BAA91121 BAA95996 BAD72976 BAD72977 BAD72978 BAD72979 BAF83158 BAG52185 BAG52343 BAG53323 CAD28457 CAD39068 EAW91937

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca