InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OAS1

Summary

InnateDB Protein

IDBP-590690.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OAS1

Protein Name

2'-5'-oligoadenylate synthetase 1, 40/46kDa

Synonyms

IFI-4; OIAS; OIASI;

Species

Homo sapiens

Ensembl Protein

ENSP00000448790

InnateDB Gene

IDBG-58231 (OAS1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	5 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0016779	nucleotidyltransferase activity

Biological Process

GO:0006955	immune response
GO:0008152	metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR002934 Nucleotidyl transferase domain
IPR006116 2-5-oligoadenylate synthetase, N-terminal
IPR018952 2\'-5\'-oligoadenylate synthetase 1, domain 2/C-terminal

PFAM

PF01909
PF10421

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-