InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: OAS1

Summary

InnateDB Gene

IDBG-58231.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OAS1

Gene Name

2'-5'-oligoadenylate synthetase 1, 40/46kDa

Synonyms

IFI-4; OIAS; OIASI

Species

Homo sapiens

Ensembl Gene

ENSG00000089127

Encoded Proteins

IDBP-58233

2'-5'-oligoadenylate synthetase 1, 40/46kDa

IDBP-383607

2'-5'-oligoadenylate synthetase 1, 40/46kDa

IDBP-383608

2'-5'-oligoadenylate synthetase 1, 40/46kDa

IDBP-591831

2'-5'-oligoadenylate synthetase 1, 40/46kDa

IDBP-590690

2'-5'-oligoadenylate synthetase 1, 40/46kDa

IDBP-594753

2'-5'-oligoadenylate synthetase 1, 40/46kDa

IDBP-587964

2'-5'-oligoadenylate synthetase 1, 40/46kDa

IDBP-603975

2'-5'-oligoadenylate synthetase 1, 40/46kDa

IDBP-809277

2'-5'-oligoadenylate synthetase 1, 40/46kDa

IDBP-809278

2'-5'-oligoadenylate synthetase 1, 40/46kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21190483

OAS1 is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the OAS1 activates RNASEL to cleave ssRNA. The OAS/RNASEL pathway triggers the RIG-I pathway and induce IFNB production.

PMID 23319625

OAS1 is a cytoplasmic dsRNA sensor.

PMID 26063222

Antiviral activity of the 2�?�,5�?�-oligoadenylate synthetase (OAS) gene variants against dengue virus shows strong and serotype-specific disparities.

Entrez Gene

Summary

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2\'-specific nucleotidyl transfer reactions to synthesize 2\',5\'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:112906777-112932185

Strand

Forward strand

Band

q24.13

Transcripts

ENST00000202917	ENSP00000202917
ENST00000445409	ENSP00000388001
ENST00000452357	ENSP00000415721
ENST00000550883	ENSP00000450286
ENST00000549820
ENST00000551241	ENSP00000448790
ENST00000553185	ENSP00000448001
ENST00000550689	ENSP00000448348
ENST00000553152	ENSP00000449053
ENST00000552526	ENSP00000475139
ENST00000540589	ENSP00000474083

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	5 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001730	2'-5'-oligoadenylate synthetase activity
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0016779	nucleotidyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006955	immune response
GO:0008152	metabolic process
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0035457	cellular response to interferon-alpha
GO:0042593	glucose homeostasis
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0051259	protein oligomerization
GO:0051607	defense response to virus
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0060700	regulation of ribonuclease activity

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_25162

Interferon alpha/beta signaling pathway

REACT_25078

Interferon gamma signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_6900

Immune System pathway

KEGG

hsa05160

Hepatitis C pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F8VUC8 Q1P9K4

UniProt Splice Variant

Entrez Gene

4938

UniGene

Hs.524760

RefSeq

NM_001032409 NM_002534 NM_016816

HUGO

HGNC:8086

OMIM

164350

CCDS

CCDS31905 CCDS41838 CCDS44980

HPRD

08879

IMGT

EMBL

AC004551 DQ473588

GenPept

ABE27978

RNA Seq Atlas

4938