InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SERPINA5

Summary

InnateDB Protein

IDBP-590800.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINA5

Protein Name

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

Synonyms

PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI;

Species

Homo sapiens

Ensembl Protein

ENSP00000451126

InnateDB Gene

IDBG-18363 (SERPINA5)

Protein Structure

UniProt Annotation

Function

Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary- type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid. {ECO:0000269PubMed:10340997, ECO:0000269PubMed:11722589, ECO:0000269PubMed:14696115, ECO:0000269PubMed:15140131, ECO:0000269PubMed:15328353, ECO:0000269PubMed:15853774, ECO:0000269PubMed:1725227, ECO:0000269PubMed:18467335, ECO:0000269PubMed:2844223, ECO:0000269PubMed:3501295, ECO:0000269PubMed:6323392, ECO:0000269PubMed:7521127, ECO:0000269PubMed:7548057, ECO:0000269PubMed:8536714, ECO:0000269PubMed:8665956, ECO:0000269PubMed:9473218, ECO:0000269PubMed:9510955, ECO:0000269PubMed:9556620}.

Subcellular Localization

Secreted, extracellular space {ECO:0000269PubMed:1725227, ECO:0000269PubMed:18467335, ECO:0000269PubMed:7521127, ECO:0000269PubMed:8536714, ECO:0000269PubMed:9510955, ECO:0000269PubMed:9556620}. Note=Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets.

Disease Associations

Tissue Specificity

Predominantly expressed in the epithelium of seminal vesicles. Expressed in the proximal tubular epithelium of the kidney. Expressed in the superficial and more differentiated epidermal keratinocytes of the skin. Expressed in megakaryocytes and platelets. Expressed poorly in kidney tumor cells compared to non tumor kidney tissues. Expressed in spermatozoa. Present in very high concentration in seminal plasma. Present in high concentration in plasma, synovial and Graaf follicle fluids. Present in low concentration in breast milk and in amniotic fluids. Present in very low concentration in urine, cerebrospinal fluids, saliva and tears (at protein level). Strongly expressed in liver. Expressed in kidney, spleen, pancreas, skeletal muscle, heart, testes, ovary, interstitial Leydig cells, epididymal glands, seminal vesicles and prostate. {ECO:0000269PubMed:1372913, ECO:0000269PubMed:14696115, ECO:0000269PubMed:15140131, ECO:0000269PubMed:17706750, ECO:0000269PubMed:18467335, ECO:0000269PubMed:9510955, ECO:0000269PubMed:9556620}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005539	glycosaminoglycan binding
GO:0008201	heparin binding
GO:0031210	phosphatidylcholine binding
GO:0032190	acrosin binding

Biological Process

GO:0006869	lipid transport
GO:0007283	spermatogenesis
GO:0007342	fusion of sperm to egg plasma membrane
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis

Cellular Component

GO:0002080	acrosomal membrane
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031091	platelet alpha granule
GO:0031094	platelet dense tubular network
GO:0036024	protein C inhibitor-TMPRSS7 complex
GO:0036025	protein C inhibitor-TMPRSS11E complex
GO:0036026	protein C inhibitor-PLAT complex
GO:0036027	protein C inhibitor-PLAU complex
GO:0036028	protein C inhibitor-thrombin complex
GO:0036029	protein C inhibitor-KLK3 complex
GO:0036030	protein C inhibitor-plasma kallikrein complex
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0097181	protein C inhibitor-coagulation factor V complex
GO:0097182	protein C inhibitor-coagulation factor Xa complex
GO:0097183	protein C inhibitor-coagulation factor XI complex