InnateDB Protein
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IDBP-590855.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ELF5
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Protein Name
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E74-like factor 5 (ets domain transcription factor)
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Synonyms
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ESE2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000436386
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InnateDB Gene
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IDBG-39323 (ELF5)
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Protein Structure
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Function |
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. {ECO:0000269PubMed:10506207}.Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters. {ECO:0000269PubMed:10506207}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00237}.
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Disease Associations |
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Tissue Specificity |
Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression. {ECO:0000269PubMed:10506207, ECO:0000269PubMed:9840936}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003118
Pointed domain
IPR013761
Sterile alpha motif/pointed domain
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PFAM |
PF02198
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PRINTS |
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PIRSF |
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SMART |
SM00251
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UKW6
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
2001
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UniGene |
Hs.11713
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RefSeq |
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HUGO |
HGNC:3320
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OMIM |
605169
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CCDS |
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HPRD |
05525
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IMGT |
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EMBL |
AF049703
AF115402
AF115403
AK074633
AK290817
AL137224
BC029743
CH471064
DQ123839
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GenPept |
AAC79755
AAD22960
AAD22961
AAH29743
AAZ98848
BAC11101
BAF83506
EAW68169
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