InnateDB Protein
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IDBP-590867.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDYN
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Protein Name
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prodynorphin
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Synonyms
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ADCA; PENKB; SCA23;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000440185
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InnateDB Gene
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IDBG-40917 (PDYN)
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Protein Structure
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Function |
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). {ECO:0000250}.Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). {ECO:0000250}.Leumorphin has a typical opiod activity and may have anti-apoptotic effect. {ECO:0000250}.
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Subcellular Localization |
Secreted.
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Disease Associations |
Spinocerebellar ataxia 23 (SCA23) [MIM:610245]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. {ECO:0000269PubMed:21035104}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0001515
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opioid peptide activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000750
Proenkephalin B
IPR006024
Opioid neuropeptide precursor
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PFAM |
PF01160
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PRINTS |
PR01030
PR01028
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P01213
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PhosphoSite |
PhosphoSite-P01213
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TrEMBL |
Q2YEM6
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UniProt Splice Variant |
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Entrez Gene |
5173
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UniGene |
Hs.22584
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RefSeq |
NP_001177828
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HUGO |
HGNC:8820
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OMIM |
131340
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CCDS |
CCDS13023
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HPRD |
08838
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IMGT |
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EMBL |
AH002816
AK289618
AK295512
AK316076
AL034562
AY902648
AY902649
AY902650
AY902651
AY902664
AY902665
AY902666
AY902667
BC026334
CH471133
K02267
X00176
X02536
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GenPept |
AAA58456
AAH26334
AAY53973
AAY53974
AAY53975
AAY53976
AAY53989
AAY53990
AAY53991
AAY53992
BAF82307
BAG58429
BAH14447
CAA24999
CAB38875
EAX10604
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