InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIK3CB

Summary

InnateDB Protein

IDBP-591255.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3CB

Protein Name

phosphoinositide-3-kinase, catalytic, beta polypeptide

Synonyms

P110BETA; PI3K; PI3KBETA; PIK3C1;

Species

Homo sapiens

Ensembl Protein

ENSP00000438259

InnateDB Gene

IDBG-58598 (PIK3CB)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0045087	innate immune response (InnateDB)
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold

PFAM

PF00454
PF00613

PRINTS

PIRSF

SMART

SM00146
SM00145

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite