Version 5.4
Homo sapiens Gene: PIK3CB
Summary
InnateDB Gene IDBG-58598.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3CB
Gene Name phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Synonyms P110BETA; PI3K; PI3KBETA; PIK3C1
Species Homo sapiens
Ensembl Gene ENSG00000051382
Encoded Proteins
IDBP-58600
phosphoinositide-3-kinase, catalytic, beta polypeptide
IDBP-483747
phosphoinositide-3-kinase, catalytic, beta polypeptide
IDBP-483742
phosphoinositide-3-kinase, catalytic, beta polypeptide
IDBP-480932
phosphoinositide-3-kinase, catalytic, beta polypeptide
IDBP-474002
phosphoinositide-3-kinase, catalytic, beta polypeptide
IDBP-476861
phosphoinositide-3-kinase, catalytic, beta polypeptide
IDBP-483431
phosphoinositide-3-kinase, catalytic, beta polypeptide
IDBP-478319
phosphoinositide-3-kinase, catalytic, beta polypeptide
IDBP-473653
phosphoinositide-3-kinase, catalytic, beta polypeptide
IDBP-480129
phosphoinositide-3-kinase, catalytic, beta polypeptide
IDBP-591255
phosphoinositide-3-kinase, catalytic, beta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20953381
PIK3CA and PIK3CB isoforms of class IA phosphatidylinositol 3-kinase (PI3K) are both required for the pro-inflammatory response to flagellin.
Entrez Gene
Summary This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:138652699-138834938
Strand Reverse strand
Band q22.3
Transcripts
ENST00000289153 ENSP00000289153
ENST00000477593 ENSP00000418143
ENST00000469284 ENSP00000419513
ENST00000462898 ENSP00000420108
ENST00000481749
ENST00000493568 ENSP00000417869
ENST00000487552
ENST00000473435 ENSP00000419091
ENST00000485060
ENST00000462294 ENSP00000418834
ENST00000483968 ENSP00000419857
ENST00000461451 ENSP00000420399
ENST00000465581 ENSP00000417329
ENST00000544716 ENSP00000438259
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560 insulin receptor substrate binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0001952 regulation of cell-matrix adhesion
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006874 cellular calcium ion homeostasis
GO:0006914 autophagy
GO:0006935 chemotaxis
GO:0007156 homophilic cell adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007596 blood coagulation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010508 positive regulation of autophagy
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016477 cell migration
GO:0030168 platelet activation
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0040016 embryonic cleavage
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0046854 phosphatidylinositol phosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0070527 platelet aggregation
GO:2000369 regulation of clathrin-mediated endocytosis
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032462
View Gene Order
ENSBTAG00000006909
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_14
IL2 pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_12555
Downstream TCR signaling pathway
REACT_23787
Regulation of signaling by CBL pathway
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_23832
Nephrin interactions pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111155
Cell-Cell communication pathway
REACT_12526
TCR signaling pathway
REACT_12529
Signaling by VEGF pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_22232
Signaling by Interleukins pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_762
IRS-related events pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_111217
Metabolism pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04150
mTOR signaling pathway pathway
hsa05221
Acute myeloid leukemia pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa00562
Inositol phosphate metabolism pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04210
Apoptosis pathway
hsa05218
Melanoma pathway
hsa05213
Endometrial cancer pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa05214
Glioma pathway
hsa05222
Small cell lung cancer pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04910
Insulin signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa05146
Amoebiasis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05145
Toxoplasmosis pathway
hsa04973
Carbohydrate digestion and absorption pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-7 signaling pathway
INOH website
B cell receptor signaling pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
IGF1 signaling pathway pathway
INOH website
Inositol phosphate metabolism pathway
INOH website
PDGF signaling pathway pathway
PID NCI
lysophospholipid_pathway
LPA receptor mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.239818 Hs.598048 Hs.740686
RefSeq NM_001256045 NM_006219 XM_005247530 XM_005247531 XM_006713659
HUGO
OMIM
CCDS CCDS3104
HPRD 04234
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca