Version 5.4
Homo sapiens Protein: ATPIF1
Summary
InnateDB Protein IDBP-591275.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATPIF1
Protein Name ATPase inhibitory factor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000437337
InnateDB Gene IDBG-95188 (ATPIF1)
Protein Structure
UniProt Annotation
Function Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269PubMed:12110673, ECO:0000269PubMed:15528193, ECO:0000269PubMed:19559621, ECO:0000269PubMed:23135403}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:12110673}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005516 calmodulin binding
GO:0042030 ATPase inhibitor activity
GO:0042803 protein homodimerization activity
GO:0043532 angiostatin binding
GO:0051117 ATPase binding
Biological Process
GO:0001525 angiogenesis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006091 generation of precursor metabolites and energy
GO:0006783 heme biosynthetic process
GO:0030218 erythrocyte differentiation
GO:0045980 negative regulation of nucleotide metabolic process
GO:0051260 protein homooligomerization
GO:0051289 protein homotetramerization
GO:0051346 negative regulation of hydrolase activity
Cellular Component
GO:0005739 mitochondrion
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0009986 cell surface
Protein Structure and Domains
PDB ID
InterPro IPR007648 ATPase inhibitor, IATP, mitochondria
PFAM PF04568
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UII2
PhosphoSite PhosphoSite-Q9UII2
TrEMBL
UniProt Splice Variant
Entrez Gene 93974
UniGene Hs.743301
RefSeq NP_835498
HUGO HGNC:871
OMIM 614981
CCDS CCDS44096
HPRD 16529
IMGT
EMBL AB029042 AF114836 AK316600 AL050386 AL353622 AL583540 AY005470 BC004955 BC009677 BT009849 CH471059 CR457097 DB030607
GenPept AAF97495 AAH04955 AAH09677 AAP88851 AAP97235 BAA88422 BAG38187 CAG33378 CAI19134 CAI46227 EAX07704

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca