Version 5.4
Homo sapiens Gene: ATPIF1
Summary
InnateDB Gene IDBG-95188.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATPIF1
Gene Name ATPase inhibitory factor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130770
Encoded Proteins
IDBP-95192
ATPase inhibitory factor 1
IDBP-588707
ATPase inhibitory factor 1
IDBP-591275
ATPase inhibitory factor 1
IDBP-595018
ATPase inhibitory factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:28236109-28246906
Strand Forward strand
Band p35.3
Transcripts
ENST00000335514 ENSP00000335203
ENST00000497986 ENSP00000435579
ENST00000465645 ENSP00000437337
ENST00000468425 ENSP00000435341
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0042030 ATPase inhibitor activity
GO:0042803 protein homodimerization activity
GO:0043532 angiostatin binding
GO:0051117 ATPase binding
Biological Process
GO:0001525 angiogenesis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006091 generation of precursor metabolites and energy
GO:0006783 heme biosynthetic process
GO:0030218 erythrocyte differentiation
GO:0045980 negative regulation of nucleotide metabolic process
GO:0051260 protein homooligomerization
GO:0051289 protein homotetramerization
GO:0051346 negative regulation of hydrolase activity
GO:0072593 reactive oxygen species metabolic process
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054428
View Gene Order
ENSBTAG00000006342
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.604600 Hs.743301
RefSeq NM_016311 NM_178190 NM_178191
HUGO
OMIM
CCDS CCDS319 CCDS320 CCDS44096
HPRD 16529
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca