InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APAF1

Summary

InnateDB Protein

IDBP-591316.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APAF1

Protein Name

apoptotic peptidase activating factor 1

Synonyms

APAF-1; CED4;

Species

Homo sapiens

Ensembl Protein

ENSP00000448161

InnateDB Gene

IDBG-52364 (APAF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043531	ADP binding

Biological Process

GO:0006952	defense response
GO:0042981	regulation of apoptotic process

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

InterPro

IPR001315 CARD domain
IPR001680 WD40 repeat
IPR002182 NB-ARC
IPR011029 Death-like domain
IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00619
PF00400
PF00931

PRINTS

PR00320

PIRSF

SMART

SM00114
SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt