InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZHX3

Summary

InnateDB Protein

IDBP-591489.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZHX3

Protein Name

zinc fingers and homeoboxes 3

Synonyms

TIX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000452965

InnateDB Gene

IDBG-75327 (ZHX3)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269PubMed:12659632, ECO:0000269PubMed:21174497}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:12659632}.

Disease Associations

Tissue Specificity

Widely expressed. High expression in kidney. Expressed during osteogenic differentiation. {ECO:0000269PubMed:12659632, ECO:0000269PubMed:21174497}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0030154	cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated