InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZHX3

Summary

InnateDB Gene

IDBG-75327.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZHX3

Gene Name

zinc fingers and homeoboxes 3

Synonyms

TIX1

Species

Homo sapiens

Ensembl Gene

ENSG00000174306

Encoded Proteins

IDBP-75329

zinc fingers and homeoboxes 3

IDBP-75335

zinc fingers and homeoboxes 3

IDBP-375297

zinc fingers and homeoboxes 3

IDBP-375305

zinc fingers and homeoboxes 3

IDBP-375309

zinc fingers and homeoboxes 3

IDBP-375310

zinc fingers and homeoboxes 3

IDBP-375315

zinc fingers and homeoboxes 3

IDBP-375320

zinc fingers and homeoboxes 3

IDBP-601163

zinc fingers and homeoboxes 3

IDBP-591489

zinc fingers and homeoboxes 3

IDBP-599021

zinc fingers and homeoboxes 3

IDBP-603123

zinc fingers and homeoboxes 3

IDBP-593747

zinc fingers and homeoboxes 3

IDBP-584969

zinc fingers and homeoboxes 3

IDBP-589155

zinc fingers and homeoboxes 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:41178448-41317672

Strand

Reverse strand

Band

q12

Transcripts

ENST00000309060	ENSP00000312222
ENST00000373261	ENSP00000362358
ENST00000421422	ENSP00000405421
ENST00000432768	ENSP00000415498
ENST00000441102	ENSP00000399433
ENST00000419740	ENSP00000400441
ENST00000436440	ENSP00000403048
ENST00000436099	ENSP00000401852
ENST00000485686
ENST00000487057
ENST00000560364	ENSP00000453647
ENST00000559234	ENSP00000452965
ENST00000558993	ENSP00000454208
ENST00000544979	ENSP00000443783
ENST00000560361	ENSP00000454006
ENST00000559436	ENSP00000453310
ENST00000561291
ENST00000560759
ENST00000560456
ENST00000559028
ENST00000559296
ENST00000540170	ENSP00000442290

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0030154	cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035877

View Gene Order

ENSBTAG00000017594

Not yet available

Cross-References

SwissProt

Q9H4I2

TrEMBL

F6UBH9 F6UQN6 F6XGA7 H0YMK8

UniProt Splice Variant

Entrez Gene

23051

UniGene

Hs.380133 Hs.736937 Hs.739970

RefSeq

NM_015035 XM_005260343 XM_006723747 XM_006723748 XM_006723749

HUGO

HGNC:15935

OMIM

609598

CCDS

CCDS13315

HPRD

10320

IMGT

EMBL

AB007855 AB081948 AL022394 AL031257 BC068569 CH471077

GenPept

AAH68569 BAA23691 BAC65211 CAA18538 EAW75987 EAW75988

RNA Seq Atlas

23051