InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LATS1

Summary

InnateDB Protein

IDBP-591516.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LATS1

Protein Name

LATS, large tumor suppressor, homolog 1 (Drosophila)

Synonyms

WARTS; wts;

Species

Homo sapiens

Ensembl Protein

ENSP00000444678

InnateDB Gene

IDBG-97771 (LATS1)

Protein Structure

UniProt Annotation

Function

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. {ECO:0000269PubMed:10518011, ECO:0000269PubMed:10831611, ECO:0000269PubMed:15122335, ECO:0000269PubMed:15220930, ECO:0000269PubMed:18158288, ECO:0000269PubMed:19927127}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:10518011}. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.

Disease Associations

Tissue Specificity

Expressed in all adult tissues examined except for lung and kidney. {ECO:0000269PubMed:10518011}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	126 [view]
Protein-Protein	121 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019901	protein kinase binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000819	sister chromatid segregation
GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0009755	hormone-mediated signaling pathway
GO:0030833	regulation of actin filament polymerization
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035329	hippo signaling
GO:0043254	regulation of protein complex assembly
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051220	cytoplasmic sequestering of protein
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0000922	spindle pole
GO:0005815	microtubule organizing center
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote

PFAM

PF00627

PRINTS

PIRSF

SMART

SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95835