InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC34A3

Summary

InnateDB Protein

IDBP-591684.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC34A3

Protein Name

solute carrier family 34 (sodium phosphate), member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000442397

InnateDB Gene

IDBG-93260 (SLC34A3)

Protein Structure

UniProt Annotation

Function

May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) [MIM:241530]: Autosomal recessive form of hypophosphatemia characterized by reduced renal phosphate reabsorption and rickets. Increased serum levels of 1,25-dihydroxyvitamin D lead to increase in urinary calcium excretion. {ECO:0000269PubMed:16358214, ECO:0000269PubMed:16358215}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005436	sodium:phosphate symporter activity
GO:0015321	sodium-dependent phosphate transmembrane transporter activity

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006817	phosphate ion transport
GO:0030643	cellular phosphate ion homeostasis
GO:0035435	phosphate ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0044341	sodium-dependent phosphate transport
GO:0055085	transmembrane transport