Version 5.4
Homo sapiens Gene: SLC34A3
Summary
InnateDB Gene IDBG-93260.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC34A3
Gene Name solute carrier family 34 (sodium phosphate), member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198569
Encoded Proteins
IDBP-93262
solute carrier family 34 (sodium phosphate), member 3
IDBP-591684
solute carrier family 34 (sodium phosphate), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:137230757-137236554
Strand Forward strand
Band q34.3
Transcripts
ENST00000361134 ENSP00000355353
ENST00000538474 ENSP00000442397
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005436 sodium:phosphate symporter activity
GO:0015321 sodium-dependent phosphate transmembrane transporter activity
Biological Process
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006817 phosphate ion transport
GO:0030643 cellular phosphate ion homeostasis
GO:0035435 phosphate ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0044341 sodium-dependent phosphate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006469
View Gene Order
ENSBTAG00000046379
Not yet available
Pathways
NETPATH
REACTOME
REACT_19411
Type II Na+/Pi cotransporters pathway
REACT_19275
Sodium-coupled phosphate cotransporters pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001177316 NM_001177317 NM_080877
HUGO
OMIM
CCDS CCDS7038
HPRD 10236
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca