InnateDB Protein
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IDBP-591687.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TNFRSF25
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Protein Name
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tumor necrosis factor receptor superfamily, member 25
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Synonyms
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APO-3; DDR3; DR3; LARD; TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000434129
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InnateDB Gene
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IDBG-227097 (TNFRSF25)
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Protein Structure
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Function |
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
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Subcellular Localization |
Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Cell membrane; Single-pass type I membrane protein.Isoform 9: Cell membrane; Single-pass type I membrane protein.Isoform 11: Cell membrane; Single-pass type I membrane protein.Isoform 3: Secreted.Isoform 4: Secreted.Isoform 5: Secreted.Isoform 6: Secreted.Isoform 7: Secreted.Isoform 8: Secreted.Isoform 10: Secreted.Isoform 12: Secreted.
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Disease Associations |
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Tissue Specificity |
Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001368
TNFR/NGFR cysteine-rich region
IPR022329
Tumour necrosis factor receptor 25
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PFAM |
PF00020
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PRINTS |
PR01972
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PIRSF |
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SMART |
SM00208
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TIGRFAMs |
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Modification |
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SwissProt |
Q93038
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8718
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UniGene |
Hs.462529
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RefSeq |
NP_001034753
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HUGO |
HGNC:11910
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OMIM |
603366
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CCDS |
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HPRD |
04532
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IMGT |
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EMBL |
AB051850
AB051851
AF026070
AF026071
AL158217
AY254324
AY358309
BC117189
BC143886
U72763
U74611
U75380
U75381
U78029
U83597
U83598
U83599
U83600
U94501
U94502
U94503
U94504
U94505
U94506
U94507
U94508
U94509
U94510
U94512
Y09392
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GenPept |
AAB39714
AAB40918
AAB41432
AAB41433
AAB41434
AAB41435
AAB82288
AAC39556
AAC50819
AAC51192
AAC51193
AAC51306
AAC51307
AAC51308
AAC51309
AAC51310
AAC51311
AAC51312
AAC51313
AAC51314
AAC51315
AAC51316
AAI17190
AAI43887
AAO63495
AAQ88676
BAB40662
BAB40663
CAA70559
CAA70560
CAA70561
CAI22153
CAI22154
CAI22155
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