Version 5.4
Homo sapiens Gene: TNFRSF25
Summary
InnateDB Gene IDBG-227097.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF25
Gene Name tumor necrosis factor receptor superfamily, member 25
Synonyms APO-3; DDR3; DR3; LARD; TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR
Species Homo sapiens
Ensembl Gene ENSG00000215788
Encoded Proteins
IDBP-87697
tumor necrosis factor receptor superfamily, member 25
IDBP-87699
tumor necrosis factor receptor superfamily, member 25
IDBP-87701
tumor necrosis factor receptor superfamily, member 25
IDBP-87705
tumor necrosis factor receptor superfamily, member 25
IDBP-87707
tumor necrosis factor receptor superfamily, member 25
IDBP-365521
tumor necrosis factor receptor superfamily, member 25
IDBP-589436
tumor necrosis factor receptor superfamily, member 25
IDBP-591687
tumor necrosis factor receptor superfamily, member 25
IDBP-475974
tumor necrosis factor receptor superfamily, member 25
IDBP-480819
tumor necrosis factor receptor superfamily, member 25
IDBP-478125
tumor necrosis factor receptor superfamily, member 25
IDBP-721741
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:6461151-6466195
Strand Reverse strand
Band p36.31
Transcripts
ENST00000356876 ENSP00000349341
ENST00000351959 ENSP00000337713
ENST00000348333 ENSP00000314451
ENST00000351748 ENSP00000326762
ENST00000377782 ENSP00000367013
ENST00000414040 ENSP00000404274
ENST00000453260
ENST00000453341
ENST00000513135
ENST00000485036 ENSP00000431554
ENST00000480393 ENSP00000434129
ENST00000473343
ENST00000502588 ENSP00000423121
ENST00000502730 ENSP00000421976
ENST00000510563 ENSP00000424071
ENST00000475730
ENST00000469691
ENST00000481401 ENSP00000465381
ENST00000461703
ENST00000515145
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042981 regulation of apoptotic process
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024793
View Gene Order
ENSBTAG00000006519
Not yet available
Pathways
NETPATH
NetPath_26
TWEAK pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt Q93038
TrEMBL
UniProt Splice Variant
Entrez Gene 8718
UniGene Hs.462529
RefSeq NM_003790 NM_148965 NM_148966 NM_148967 NM_148970
HUGO HGNC:11910
OMIM 603366
CCDS CCDS71 CCDS72 CCDS73 CCDS74 CCDS75
HPRD 04532
IMGT
EMBL AB051850 AB051851 AF026070 AF026071 AL158217 AY254324 AY358309 BC117189 BC143886 U72763 U74611 U75380 U75381 U78029 U83597 U83598 U83599 U83600 U94501 U94502 U94503 U94504 U94505 U94506 U94507 U94508 U94509 U94510 U94512 Y09392
GenPept AAB39714 AAB40918 AAB41432 AAB41433 AAB41434 AAB41435 AAB82288 AAC39556 AAC50819 AAC51192 AAC51193 AAC51306 AAC51307 AAC51308 AAC51309 AAC51310 AAC51311 AAC51312 AAC51313 AAC51314 AAC51315 AAC51316 AAI17190 AAI43887 AAO63495 AAQ88676 BAB40662 BAB40663 CAA70559 CAA70560 CAA70561 CAI22153 CAI22154 CAI22155
RNA Seq Atlas 8718

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca