InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACER3

Summary

InnateDB Protein

IDBP-591699.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACER3

Protein Name

alkaline ceramidase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000434480

InnateDB Gene

IDBG-65242 (ACER3)

Protein Structure

UniProt Annotation

Function

Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highest expression in placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0070774	phytoceramidase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006672	ceramide metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0030148	sphingolipid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046512	sphingosine biosynthetic process
GO:0071602	phytosphingosine biosynthetic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0030173	integral component of Golgi membrane
GO:0030176	integral component of endoplasmic reticulum membrane