Version 5.4
Homo sapiens Protein: KCNC4
Summary
InnateDB Protein IDBP-591791.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNC4
Protein Name potassium voltage-gated channel, Shaw-related subfamily, member 4
Synonyms C1orf30; HKSHIIIC; KSHIIIC; KV3.4;
Species Homo sapiens
Ensembl Protein ENSP00000436656
InnateDB Gene IDBG-100963 (KCNC4)
Protein Structure
UniProt Annotation
Function This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003971 Potassium channel, voltage dependent, Kv9
IPR003974 Potassium channel, voltage dependent, Kv3
IPR005405 Potassium channel, voltage dependent, Kv3.4
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain
IPR021105 Potassium channel, voltage dependent, Kv3, inactivation domain
PFAM PF02214
PF00520
PF07885
PF11404
PRINTS PR00169
PR01491
PR01494
PR01498
PR01583
PIRSF
SMART SM00225
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q03721
PhosphoSite PhosphoSite-Q03721
TrEMBL
UniProt Splice Variant
Entrez Gene 3749
UniGene Hs.153521
RefSeq
HUGO HGNC:6236
OMIM 176265
CCDS CCDS821
HPRD 08887
IMGT
EMBL AL137790 BC019010 BC101769 M64676
GenPept AAA57263 AAI01770 CAI18831

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca