Version 5.4
Homo sapiens Gene: KCNC4
Summary
InnateDB Gene IDBG-100963.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNC4
Gene Name potassium voltage-gated channel, Shaw-related subfamily, member 4
Synonyms C1orf30; HKSHIIIC; KSHIIIC; KV3.4
Species Homo sapiens
Ensembl Gene ENSG00000116396
Encoded Proteins
IDBP-100965
potassium voltage-gated channel, Shaw-related subfamily, member 4
IDBP-387616
potassium voltage-gated channel, Shaw-related subfamily, member 4
IDBP-387617
potassium voltage-gated channel, Shaw-related subfamily, member 4
IDBP-591791
potassium voltage-gated channel, Shaw-related subfamily, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:110211343-110283100
Strand Forward strand
Band p13.3
Transcripts
ENST00000369787 ENSP00000358802
ENST00000438661 ENSP00000393655
ENST00000413138 ENSP00000388029
ENST00000412512
ENST00000469655 ENSP00000436656
ENST00000489935
ENST00000459877
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0046928 regulation of neurotransmitter secretion
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0031594 neuromuscular junction
GO:0043679 axon terminus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027895
View Gene Order
ENSBTAG00000007352
Not yet available
Pathways
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.153521
RefSeq NM_001039574 NM_004978 XM_006710627
HUGO
OMIM
CCDS CCDS44193 CCDS821
HPRD 08887
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca