InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP1A3

Summary

InnateDB Protein

IDBP-591838.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP1A3

Protein Name

ATPase, Na+/K+ transporting, alpha 3 polypeptide

Synonyms

AHC2; DYT12; RDP;

Species

Homo sapiens

Ensembl Protein

ENSP00000444688

InnateDB Gene

IDBG-53554 (ATP1A3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0031748	D1 dopamine receptor binding
GO:0046872	metal ion binding

Biological Process

GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0007613	memory
GO:0008344	adult locomotory behavior
GO:0008542	visual learning
GO:0015672	monovalent inorganic cation transport
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035725	sodium ion transmembrane transport
GO:0042493	response to drug
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043209	myelin sheath
GO:0044326	dendritic spine neck
GO:0044327	dendritic spine head
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt