InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF7

Summary

InnateDB Protein

IDBP-59185.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF7

Protein Name

ring finger protein 7

Synonyms

CKBBP1; ROC2; SAG;

Species

Homo sapiens

Ensembl Protein

ENSP00000273480

InnateDB Gene

IDBG-59181 (RNF7)

Protein Structure

UniProt Annotation

Function

Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. {ECO:0000269PubMed:10851089}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10082581}. Nucleus {ECO:0000269PubMed:10082581}.

Disease Associations

Tissue Specificity

Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung. {ECO:0000269PubMed:10512750}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	72 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019788	NEDD8 ligase activity

Biological Process

GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0016567	protein ubiquitination
GO:0043066	negative regulation of apoptotic process
GO:0045116	protein neddylation
GO:0051775	response to redox state