Version 5.4
Homo sapiens Gene: RNF7
Summary
InnateDB Gene IDBG-59181.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF7
Gene Name ring finger protein 7
Synonyms CKBBP1; ROC2; SAG
Species Homo sapiens
Ensembl Gene ENSG00000114125
Encoded Proteins
IDBP-59185
ring finger protein 7
IDBP-244506
ring finger protein 7
IDBP-484063
ring finger protein 7
IDBP-477883
ring finger protein 7
IDBP-475795
ring finger protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:141738204-141747560
Strand Forward strand
Band q23
Transcripts
ENST00000273480 ENSP00000273480
ENST00000393000 ENSP00000376725
ENST00000498828
ENST00000480908 ENSP00000419084
ENST00000477012 ENSP00000419339
ENST00000477393 ENSP00000419979
ENST00000486377
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 74 [view]
Protein-Protein 72 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019788 NEDD8 ligase activity
Biological Process
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0016567 protein ubiquitination
GO:0043066 negative regulation of apoptotic process
GO:0045116 protein neddylation
GO:0051775 response to redox state
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031466 Cul5-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051234
View Gene Order
ENSBTAG00000002185
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597614 Hs.644754
RefSeq NM_001201370 NM_014245 NM_183237
HUGO
OMIM
CCDS CCDS3118 CCDS43158 CCDS56283
HPRD 04840
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca