InnateDB Protein
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IDBP-592154.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CALU
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Protein Name
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calumenin
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000438248
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InnateDB Gene
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IDBG-39925 (CALU)
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Protein Structure
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Function |
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
85
[view]
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Protein-Protein |
84
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002048
EF-hand domain
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PFAM |
PF00036
PF13202
PF13405
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PRINTS |
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PIRSF |
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SMART |
SM00054
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TIGRFAMs |
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Modification |
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SwissProt |
O43852
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PhosphoSite |
PhosphoSite-O43852
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TrEMBL |
A0A024R755
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UniProt Splice Variant |
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Entrez Gene |
813
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UniGene |
Hs.7753
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RefSeq |
NP_001186601
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HUGO |
HGNC:1458
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OMIM |
603420
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CCDS |
CCDS56507
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HPRD |
04569
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IMGT |
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EMBL |
AC024952
AF013759
AF257659
AF345637
AK056338
BC013383
CH471070
CR541835
HM002604
HM002605
HM002606
HM002607
HM002608
HM002609
HM002610
HM002611
HM002612
HM002613
HM002614
HM002615
HM002616
U67280
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GenPept |
AAB97725
AAC17216
AAF76141
AAH13383
AAK72908
ADG45004
ADG45005
ADG45006
ADG45007
ADG45008
ADG45009
ADG45010
ADG45011
ADG45012
ADG45013
ADG45014
ADG45015
ADG45016
BAG51681
CAG46634
EAW83674
EAW83675
EAW83676
EAW83679
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