Version 5.4
Homo sapiens Protein: PTPN22
Summary
InnateDB Protein IDBP-592333.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN22
Protein Name protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000435176
InnateDB Gene IDBG-101222 (PTPN22)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0017124 SH3 domain binding
GO:0019900 kinase binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0030217 T cell differentiation
GO:0032817 regulation of natural killer cell proliferation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035644 phosphoanandamide dephosphorylation
GO:0045088 regulation of innate immune response
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009898 cytoplasmic side of plasma membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PRINTS PR00700
PIRSF
SMART SM00194
SM00404
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2R2
PhosphoSite PhosphoSite-Q9Y2R2
TrEMBL
UniProt Splice Variant
Entrez Gene 26191
UniGene Hs.535276
RefSeq NP_036543
HUGO HGNC:9652
OMIM 600716
CCDS CCDS864
HPRD 06100
IMGT
EMBL AF001846 AF001847 AF077031 AK310570 AL137856 BC017785 BC071670 CH471122 EF064714 GU479452
GenPept AAD00904 AAD00905 AAD27764 AAH17785 AAH71670 ABK41897 ADD59979 CAI19068 EAW56575 EAW56576

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca