Homo sapiens Protein: SYTL2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-592377.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | SYTL2 | ||||||||||||||||||||||
Protein Name | synaptotagmin-like 2 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000431701 | ||||||||||||||||||||||
InnateDB Gene | IDBG-66497 (SYTL2) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol- 4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon- containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269PubMed:17182843, ECO:0000269PubMed:18266782, ECO:0000269PubMed:18812475}. | ||||||||||||||||||||||
Subcellular Localization | Isoform 1: Cytoplasm. Cell membrane. Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A.Isoform 4: Cell membrane. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells. {ECO:0000269PubMed:17182843, ECO:0000269PubMed:18266782, ECO:0000269PubMed:18812475}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000008
C2 domain IPR010911 Zinc finger, FYVE-type IPR011011 Zinc finger, FYVE/PHD-type |
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PFAM |
PF00168
PF02318 |
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PRINTS |
PR00360
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PIRSF | |||||||||||||||||||||||
SMART |
SM00239
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9HCH5 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9HCH5 | ||||||||||||||||||||||
TrEMBL | Q9BQS1 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 54843 | ||||||||||||||||||||||
UniGene | Hs.596233 | ||||||||||||||||||||||
RefSeq | NP_001156423 | ||||||||||||||||||||||
HUGO | HGNC:15585 | ||||||||||||||||||||||
OMIM | 612880 | ||||||||||||||||||||||
CCDS | CCDS53688 | ||||||||||||||||||||||
HPRD | 10260 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB046817 AJ303364 AK000170 AK024872 AK074737 AK092121 AK124754 AK127504 AK131365 AK296224 AK296740 AK298604 AL834422 AP000642 AP000974 AY386362 BC015540 BC110315 BC136450 BC144114 BC144115 CH471076 EU035829 | ||||||||||||||||||||||
GenPept | AAH15540 AAI10316 AAI36451 AAI44115 AAI44116 AAR25619 ABV82746 BAA90989 BAB13423 BAB15030 BAC11170 BAC85937 BAD18516 BAG52485 BAG58947 BAG59325 BAG60788 CAC33886 CAD39083 EAW75108 EAW75110 EAW75113 | ||||||||||||||||||||||