InnateDB Protein
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IDBP-592426.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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STX16
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Protein Name
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syntaxin 16
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Synonyms
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SYN16;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000434369
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InnateDB Gene
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IDBG-82615 (STX16)
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Protein Structure
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Function |
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269PubMed:18195106}.
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Subcellular Localization |
Golgi apparatus membrane; Single-pass type IV membrane protein.Isoform C: Cytoplasm.
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Disease Associations |
Pseudohypoparathyroidism 1B (PHP1B) [MIM:603233]: A disorder characterized by end-organ resistance to parathyroid hormone, hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. {ECO:0000269PubMed:14561710, ECO:0000269PubMed:15800843}. Note=The gene represented in this entry is involved in disease pathogenesis. Microdeletions involving STX16 can cause loss of methylation at exon A/B of GNAS, resulting in PHP1B.
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006011
Syntaxin, N-terminal domain
IPR010989
t-SNARE
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PFAM |
PF00804
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PRINTS |
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PIRSF |
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SMART |
SM00503
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TIGRFAMs |
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Modification |
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SwissProt |
O14662
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PhosphoSite |
PhosphoSite-O14662
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TrEMBL |
E9PND6
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UniProt Splice Variant |
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Entrez Gene |
8675
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UniGene |
Hs.610411
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RefSeq |
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HUGO |
HGNC:11431
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OMIM |
603666
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CCDS |
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HPRD |
04718
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IMGT |
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EMBL |
AF008935
AF008936
AF008937
AF038897
AL050327
AL139349
BC019042
BC073876
BX396221
CH471077
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GenPept |
AAB69282
AAB69283
AAB69284
AAC05647
AAH19042
AAH73876
CAI23277
CAI23278
CAI23279
CAM28341
CAX14989
CAX14990
CAX14991
CAX14992
EAW75481
EAW75482
EAW75484
EAW75485
EAW75486
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