InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STX16

Summary

InnateDB Gene

IDBG-82615.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STX16

Gene Name

syntaxin 16

Synonyms

SYN16

Species

Homo sapiens

Ensembl Gene

ENSG00000124222

Encoded Proteins

IDBP-82617

syntaxin 16

IDBP-82619

syntaxin 16

IDBP-82627

syntaxin 16

IDBP-82629

syntaxin 16

IDBP-82631

syntaxin 16

IDBP-82633

syntaxin 16

IDBP-82635

syntaxin 16

IDBP-82637

syntaxin 16

IDBP-379412

syntaxin 16

IDBP-379414

syntaxin 16

IDBP-379418

syntaxin 16

IDBP-592609

syntaxin 16

IDBP-599539

syntaxin 16

IDBP-597403

syntaxin 16

IDBP-592426

syntaxin 16

IDBP-597785

syntaxin 16

IDBP-602735

syntaxin 16

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:58651253-58679526

Strand

Forward strand

Band

q13.32

Transcripts

ENST00000355957	ENSP00000348229
ENST00000371141	ENSP00000360183
ENST00000361830	ENSP00000354445
ENST00000358029	ENSP00000350723
ENST00000371132	ENSP00000360173
ENST00000361770	ENSP00000355408
ENST00000359617	ENSP00000352634
ENST00000312283	ENSP00000312086
ENST00000458280	ENSP00000388348
ENST00000412911	ENSP00000416852
ENST00000438253	ENSP00000401801
ENST00000460655	ENSP00000435118
ENST00000476384	ENSP00000437209
ENST00000483434	ENSP00000432823
ENST00000496117
ENST00000490700
ENST00000496003
ENST00000467096	ENSP00000434369
ENST00000464640	ENSP00000432414
ENST00000493301	ENSP00000436667
ENST00000468590

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005484	SNAP receptor activity
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006891	intra-Golgi vesicle-mediated transport
GO:0016192	vesicle-mediated transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0000139	Golgi membrane
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031201	SNARE complex
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027522

View Gene Order

ENSBTAG00000003872

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04130

SNARE interactions in vesicular transport pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.307913 Hs.595479 Hs.608757 Hs.610411

RefSeq

NM_001001433 NM_001134772 NM_001134773 NM_001204868 NM_003763

HUGO

OMIM

CCDS

CCDS13468 CCDS13469 CCDS46619 CCDS46620 CCDS56199

HPRD

04718

IMGT

EMBL

GenPept

RNA Seq Atlas