InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCL2L2-PABPN1

Summary

InnateDB Protein

IDBP-592540.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2L2-PABPN1

Protein Name

BCL2L2-PABPN1 readthrough

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000452479

InnateDB Gene

IDBG-547352 (BCL2L2-PABPN1)

Protein Structure

UniProt Annotation

Function

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. {ECO:0000269PubMed:8761287}.

Subcellular Localization

Mitochondrion membrane {ECO:0000269PubMed:11423909, ECO:0000269PubMed:12952938}; Peripheral membrane protein {ECO:0000269PubMed:11423909, ECO:0000269PubMed:12952938}. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.

Disease Associations

Tissue Specificity

Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. {ECO:0000269PubMed:11423909}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007283	spermatogenesis
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR002475 Bcl2-like
IPR003093 Apoptosis regulator, Bcl-2 protein, BH4
IPR013280 Apoptosis regulator, Bcl-W
IPR026298 Blc2 family

PFAM

PF00076
PF02180
PF00452

PRINTS

PR01865
PR01862

PIRSF

SMART

SM00360
SM00265

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt