InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC5A8

Summary

InnateDB Protein

IDBP-592679.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC5A8

Protein Name

solute carrier family 5 (iodide transporter), member 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000445340

InnateDB Gene

IDBG-547244 (SLC5A8)

Protein Structure

UniProt Annotation

Function

Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. {ECO:0000269PubMed:12107270, ECO:0000269PubMed:12829793, ECO:0000269PubMed:14966140, ECO:0000269PubMed:15090606, ECO:0000269PubMed:15361710, ECO:0000269PubMed:15867356, ECO:0000269PubMed:16729224, ECO:0000269PubMed:16805814, ECO:0000269PubMed:17178845, ECO:0000269PubMed:17245649, ECO:0000269PubMed:18037591}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:12107270, ECO:0000269PubMed:15001644, ECO:0000269PubMed:17245649}; Multi-pass membrane protein {ECO:0000269PubMed:12107270, ECO:0000269PubMed:15001644, ECO:0000269PubMed:17245649}. Note=Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells. {ECO:0000269PubMed:12107270, ECO:0000269PubMed:15001644, ECO:0000269PubMed:17245649}.

Disease Associations

Tissue Specificity

Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors. {ECO:0000269PubMed:12107270, ECO:0000269PubMed:12829793, ECO:0000269PubMed:14966140, ECO:0000269PubMed:15001644, ECO:0000269PubMed:15090606, ECO:0000269PubMed:15361710, ECO:0000269PubMed:15867356, ECO:0000269PubMed:17178845, ECO:0000269PubMed:17245649, ECO:0000269PubMed:18037591}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0015293	symporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006915	apoptotic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome