InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZFHX3

Summary

InnateDB Protein

IDBP-592955.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFHX3

Protein Name

zinc finger homeobox 3

Synonyms

ATBF1; ATBT; ZNF927;

Species

Homo sapiens

Ensembl Protein

ENSP00000438926

InnateDB Gene

IDBG-41820 (ZFHX3)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down- regulates the MUC5AC promoter in gastric cancer. {ECO:0000269PubMed:11312261, ECO:0000269PubMed:17330845}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). {ECO:0000269PubMed:17330845}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003779	actin binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007010	cytoskeleton organization
GO:0007517	muscle organ development
GO:0045662	negative regulation of myoblast differentiation
GO:0045663	positive regulation of myoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR001356 Homeobox domain
IPR003604 Zinc finger, U1-type
IPR007087 Zinc finger, C2H2
IPR009057 Homeodomain-like
IPR013992 Adenylate cyclase-associated CAP, N-terminal
IPR015880 Zinc finger, C2H2-like

PFAM

PF00046
PF00096
PF01213

PRINTS

PIRSF

SMART

SM00389
SM00451
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15911