InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZFHX3

Summary

InnateDB Gene

IDBG-41820.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFHX3

Gene Name

zinc finger homeobox 3

Synonyms

ATBF1; ATBT; ZNF927

Species

Homo sapiens

Ensembl Gene

ENSG00000140836

Encoded Proteins

IDBP-41822

zinc finger homeobox 3

IDBP-592955

zinc finger homeobox 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:72782885-73059698

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000268489	ENSP00000268489
ENST00000397992	ENSP00000438926
ENST00000563625

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003779	actin binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007010	cytoskeleton organization
GO:0007050	cell cycle arrest
GO:0007420	brain development
GO:0007517	muscle organ development
GO:0045662	negative regulation of myoblast differentiation
GO:0045663	positive regulation of myoblast differentiation
GO:0045664	regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038872

View Gene Order

ENSBTAG00000014636

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

cmyb_pathway

C-MYB transcription factor network

Cross-References

SwissProt

Q15911

TrEMBL

UniProt Splice Variant

Entrez Gene

463

UniGene

Hs.598297 Hs.606373

RefSeq

NM_001164766 NM_006885 XM_005255957

HUGO

HGNC:777

OMIM

104155

CCDS

CCDS54035 CCDS10908

HPRD

00075

IMGT

EMBL

AC002044 AC004943 AC132068 CH471166 D10250 L32832

GenPept

AAC14462 AAC31674 AAC79153 BAA01095 EAW59168 EAW59170

RNA Seq Atlas

463