Version 5.4
Homo sapiens Protein: PKD1L2
Summary
InnateDB Protein IDBP-592974.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKD1L2
Protein Name polycystic kidney disease 1-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000432818
InnateDB Gene IDBG-43476 (PKD1L2)
Protein Structure
UniProt Annotation
Function May function as an ion-channel regulator. May function as a G-protein-coupled receptor. {ECO:0000269PubMed:15203210}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in all tissues tested including brain, placenta, mammary gland, testis, lung and liver. Highest expression in skeletal muscle. Isoform 2 is expressed in heart and kidney. {ECO:0000269PubMed:12782129}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR014010 Egg jelly receptor, REJ-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z442
PhosphoSite PhosphoSite-Q7Z442
TrEMBL
UniProt Splice Variant
Entrez Gene 114780
UniGene Hs.737982
RefSeq
HUGO HGNC:21715
OMIM 607894
CCDS
HPRD 06990
IMGT
EMBL AB067466 AC092718 AC131888 AK098052 AK127266 AK131378 AY164483 AY371495 BC004562 BC014157
GenPept AAH04562 AAH14157 AAO32796 AAQ73173 BAB67772 BAC05222 BAC86906 BAD18529

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca