Version 5.4
Homo sapiens Protein: HRK
Summary
InnateDB Protein IDBP-59299.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRK
Protein Name harakiri, BCL2 interacting protein (contains only BH3 domain)
Synonyms DP5; HARAKIRI;
Species Homo sapiens
Ensembl Protein ENSP00000257572
InnateDB Gene IDBG-59297 (HRK)
Protein Structure
UniProt Annotation
Function Promotes apoptosis. {ECO:0000269PubMed:15031724, ECO:0000269PubMed:9130713}.
Subcellular Localization Membrane; Single-pass membrane protein. Mitochondrion.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0032464 positive regulation of protein homooligomerization
GO:0043065 positive regulation of apoptotic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR017249 Activator of apoptosis harakiri
PFAM PF15196
PRINTS
PIRSF PIRSF037635
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00198
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 8739
UniGene Hs.87247
RefSeq NP_003797
HUGO HGNC:5185
OMIM 603447
CCDS CCDS9181
HPRD 04581
IMGT
EMBL AC083806 U76376
GenPept AAC34931

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca