Homo sapiens Gene: HRK
Summary
InnateDB Gene IDBG-59297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRK
Gene Name harakiri, BCL2 interacting protein (contains only BH3 domain)
Synonyms DP5; HARAKIRI
Species Homo sapiens
Ensembl Gene ENSG00000135116
Encoded Proteins
harakiri, BCL2 interacting protein (contains only BH3 domain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:116856144-116881441
Strand Reverse strand
Band q24.22
Transcripts
ENST00000257572 ENSP00000257572
ENST00000552092
ENST00000550505 ENSP00000465379
ENST00000586941
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0032464 positive regulation of protein homooligomerization
GO:0043065 positive regulation of apoptotic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ATF-2 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8739
UniGene Hs.26605 Hs.610726 Hs.670943 Hs.87247
RefSeq NM_003806
HUGO HGNC:5185
OMIM 603447
CCDS CCDS9181
HPRD 04581
IMGT
EMBL
GenPept
RNA Seq Atlas 8739