InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2J1

Summary

InnateDB Protein

IDBP-593024.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2J1

Protein Name

ubiquitin-conjugating enzyme E2, J1, U

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000451261

InnateDB Gene

IDBG-94305 (UBE2J1)

Protein Structure

UniProt Annotation

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). {ECO:0000255PROSITE-ProRule:PRU00388, ECO:0000269PubMed:12082160, ECO:0000269PubMed:22607976}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12082160}; Single-pass type IV membrane protein {ECO:0000269PubMed:12082160}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0016567	protein ubiquitination
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process