InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPN21

Summary

InnateDB Protein

IDBP-593145.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN21

Protein Name

protein tyrosine phosphatase, non-receptor type 21

Synonyms

PTPD1; PTPRL10;

Species

Homo sapiens

Ensembl Protein

ENSP00000452414

InnateDB Gene

IDBG-15012 (PTPN21)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000299 FERM domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR014392 Protein-tyrosine phosphatase, non-receptor type-14, -21
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029021 Protein-tyrosine phosphatase-like
IPR029071 Ubiquitin-related domain

PFAM

PF00102
PF09379
PF09380
PF00373

PRINTS

PR00700
PR00935

PIRSF

PIRSF000934

SMART

SM00194
SM00404
SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References