Version 5.4
| Homo sapiens Gene: PTPN21 | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-15012.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PTPN21 | ||||||||||||||||||
| Gene Name | protein tyrosine phosphatase, non-receptor type 21 | ||||||||||||||||||
| Synonyms | PTPD1; PTPRL10 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000070778 | ||||||||||||||||||
| Encoded Proteins |
protein tyrosine phosphatase, non-receptor type 21
protein tyrosine phosphatase, non-receptor type 21
protein tyrosine phosphatase, non-receptor type 21
protein tyrosine phosphatase, non-receptor type 21
protein tyrosine phosphatase, non-receptor type 21
|
||||||||||||||||||
| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008] |
||||||||||||||||||
| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 14:88465778-88554733 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q31.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
| Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
| Biological Process |
|
||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||
| Orthologs | |||||||||||||||||||
|
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI |
Signaling events mediated by focal adhesion kinase
|
||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | H0YJ59 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 11099 | ||||||||||||||||||
| UniGene | Hs.437040 Hs.714058 | ||||||||||||||||||
| RefSeq | NM_007039 XM_005267287 | ||||||||||||||||||
| HUGO | HGNC:9651 | ||||||||||||||||||
| OMIM | 603271 | ||||||||||||||||||
| CCDS | CCDS9884 | ||||||||||||||||||
| HPRD | 04468 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AL049834 AL162171 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 11099 | ||||||||||||||||||