InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNA13

Summary

InnateDB Protein

IDBP-593246.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNA13

Protein Name

guanine nucleotide binding protein (G protein), alpha 13

Synonyms

G13;

Species

Homo sapiens

Ensembl Protein

ENSP00000439647

InnateDB Gene

IDBG-64978 (GNA13)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031702	type 1 angiotensin receptor binding
GO:0031752	D5 dopamine receptor binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006928	cellular component movement
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007266	Rho protein signal transduction
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0031584	activation of phospholipase D activity

Cellular Component

GO:0005634	nucleus
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031526	brush border membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000469 G-protein alpha subunit, group 12
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00025

PRINTS

PR00440
PR00318
PR00328

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt