InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXW8

Summary

InnateDB Protein

IDBP-59329.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXW8

Protein Name

F-box and WD repeat domain containing 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000310686

InnateDB Gene

IDBG-59327 (FBXW8)

Protein Structure

UniProt Annotation

Function

Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000269PubMed:18498745, ECO:0000269PubMed:21572988, ECO:0000269PubMed:24362026, ECO:0000269PubMed:24793695}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:21572988}. Golgi apparatus {ECO:0000269PubMed:21572988}. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0007030	Golgi organization
GO:0008283	cell proliferation
GO:0016567	protein ubiquitination
GO:0050775	positive regulation of dendrite morphogenesis
GO:0060712	spongiotrophoblast layer development
GO:0060716	labyrinthine layer blood vessel development

Cellular Component

GO:0005794	Golgi apparatus
GO:0019005	SCF ubiquitin ligase complex
GO:0031467	Cul7-RING ubiquitin ligase complex
GO:0048471	perinuclear region of cytoplasm
GO:1990393	3M complex