InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WFIKKN2

Summary

InnateDB Protein

IDBP-59340.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WFIKKN2

Protein Name

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000311184

InnateDB Gene

IDBG-59338 (WFIKKN2)

Protein Structure

UniProt Annotation

Function

Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney. {ECO:0000269PubMed:11928817}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008191	metalloendopeptidase inhibitor activity
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0001501	skeletal system development
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010951	negative regulation of endopeptidase activity
GO:0032091	negative regulation of protein binding
GO:0043392	negative regulation of DNA binding
GO:0048747	muscle fiber development
GO:0060021	palate development

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR001134 Netrin domain
IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR002350 Kazal domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR008197 Whey acidic protein-type 4-disulphide core
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR018933 Netrin module, non-TIMP type

PFAM