InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLCZ1

Summary

InnateDB Protein

IDBP-593457.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCZ1

Protein Name

phospholipase C, zeta 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000445880

InnateDB Gene

IDBG-21958 (PLCZ1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006816	calcium ion transport
GO:0007165	signal transduction
GO:0007343	egg activation
GO:0008152	metabolic process
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00168
PF00388
PF00387

PRINTS

PR00360
PR00390

PIRSF

SMART

SM00239
SM00148
SM00149

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt