Version 5.4
Homo sapiens Gene: PLCZ1
Summary
InnateDB Gene IDBG-21958.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCZ1
Gene Name phospholipase C, zeta 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139151
Encoded Proteins
IDBP-21960
phospholipase C, zeta 1
IDBP-21962
phospholipase C, zeta 1
IDBP-594561
phospholipase C, zeta 1
IDBP-599328
phospholipase C, zeta 1
IDBP-595681
phospholipase C, zeta 1
IDBP-593457
phospholipase C, zeta 1
IDBP-597940
phospholipase C, zeta 1
IDBP-595821
phospholipase C, zeta 1
IDBP-591287
phospholipase C, zeta 1
IDBP-600488
phospholipase C, zeta 1
IDBP-597941
phospholipase C, zeta 1
IDBP-601859
phospholipase C, zeta 1
IDBP-598299
phospholipase C, zeta 1
IDBP-597912
phospholipase C, zeta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:18683169-18738057
Strand Reverse strand
Band p12.3
Transcripts
ENST00000266505 ENSP00000266505
ENST00000318197 ENSP00000326397
ENST00000536023 ENSP00000438679
ENST00000534932 ENSP00000438826
ENST00000543219 ENSP00000445287
ENST00000538330 ENSP00000445880
ENST00000540270 ENSP00000443320
ENST00000539875 ENSP00000445026
ENST00000540421 ENSP00000445889
ENST00000542762
ENST00000540515
ENST00000543242 ENSP00000443762
ENST00000539072 ENSP00000438629
ENST00000539207 ENSP00000444611
ENST00000545129
ENST00000535429 ENSP00000440781
ENST00000541966 ENSP00000444383
ENST00000541109
ENST00000544849
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006816 calcium ion transport
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007343 egg activation
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030230
View Gene Order
ENSBTAG00000013202
Not yet available
Pathways
NETPATH
REACTOME
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04020
Calcium signaling pathway pathway
hsa04114
Oocyte meiosis pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.743832 Hs.97542
RefSeq NM_033123
HUGO
OMIM
CCDS CCDS8680
HPRD 06996
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca