Homo sapiens Gene: PLCZ1
Summary
InnateDB Gene IDBG-21958.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol PLCZ1
Gene Name phospholipase C, zeta 1
Synonyms NYD-SP27; PLC-zeta-1; PLCzeta;
Species Homo sapiens
Ensembl Gene ENSG00000139151
Encoded Proteins
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
phospholipase C, zeta 1
Protein Structure
Entrez Gene
Summary The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:18836103-18890991
Strand Reverse strand
Band p12.3
Transcripts
ENST00000266505 ENSP00000266505
ENST00000318197 ENSP00000326397
ENST00000435379 ENSP00000400504
ENST00000447925 ENSP00000402358
ENST00000536023 ENSP00000438679
ENST00000534932 ENSP00000438826
ENST00000543219 ENSP00000445287
ENST00000538330 ENSP00000445880
ENST00000540270 ENSP00000443320
ENST00000539875 ENSP00000445026
ENST00000540421 ENSP00000445889
ENST00000542762
ENST00000540515
ENST00000543242 ENSP00000443762
ENST00000539072 ENSP00000438629
ENST00000539207 ENSP00000444611
ENST00000545129
ENST00000535429 ENSP00000440781
ENST00000541966 ENSP00000444383
ENST00000541109
ENST00000544849
ENST00000541695 ENSP00000443349
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006816 calcium ion transport
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007343 egg activation
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Oocyte meiosis pathway
Metabolic pathways pathway
Phosphatidylinositol signaling system pathway
Calcium signaling pathway pathway
Inositol phosphate metabolism pathway
INOH
Inositol phosphate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q86YW0
TrEMBL C9IZ68 F5GYE4 F5GZK3 F5H2D7 F5H2Y6 F5H3L4 F5H474 F5H828 H0YGY7 H0YH40 Q8N7S5 Q8N7X7
UniProt Splice Variant
Entrez Gene 89869
UniGene Hs.743832 Hs.97542
RefSeq NM_033123
HUGO 19218
OMIM 608075
CCDS CCDS8680
HPRD 06996
IMGT
EMBL AC087242 AF532185 AK097555 AK097725 AK292279 AY035866 BC125067
GenPept AAI25068 AAK61372 AAN71895 BAC05099 BAC05152 BAF84968
ImmGen PLCZ1 (murine)
RNA Seq Atlas 89869