InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NXN

Summary

InnateDB Protein

IDBP-593525.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NXN

Protein Name

nucleoredoxin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000446446

InnateDB Gene

IDBG-14319 (NXN)

Protein Structure

UniProt Annotation

Function

Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0047134	protein-disulfide reductase activity

Biological Process

GO:0016055	Wnt signaling pathway
GO:0030154	cell differentiation
GO:0030178	negative regulation of Wnt signaling pathway
GO:0031397	negative regulation of protein ubiquitination
GO:0045087	innate immune response (InnateDB)
GO:0055114	oxidation-reduction process
GO:0072358	cardiovascular system development