Version 5.4
Homo sapiens Gene: NXN
Summary
InnateDB Gene IDBG-14319.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NXN
Gene Name nucleoredoxin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167693
Encoded Proteins
IDBP-14323
nucleoredoxin
IDBP-593525
nucleoredoxin
IDBP-762082
IDBP-764562
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20400501
NXN subfamily of proteins form a link between MYD88 and FLII (flightless I) to mediate negative regulation of the TLR4/MYD88 pathway.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:799313-979770
Strand Reverse strand
Band p13.3
Transcripts
ENST00000336868 ENSP00000337443
ENST00000537628 ENSP00000446446
ENST00000577098
ENST00000574018
ENST00000575171
ENST00000576991
ENST00000571338
ENST00000571080
ENST00000575455
ENST00000575801 ENSP00000461038
ENST00000571684 ENSP00000461562
ENST00000571281
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004791 thioredoxin-disulfide reductase activity
GO:0005515 protein binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0047134 protein-disulfide reductase activity
Biological Process
GO:0016055 Wnt signaling pathway
GO:0030154 cell differentiation
GO:0030178 negative regulation of Wnt signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0045087 innate immune response (InnateDB)
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
GO:0072358 cardiovascular system development
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020844
View Gene Order
ENSBTAG00000000855
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.527989 Hs.676198
RefSeq NM_001205319 NM_022463 XM_005256757 XM_005256758
HUGO
OMIM
CCDS CCDS10998 CCDS56013
HPRD 14858
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca