Version 5.4
Homo sapiens Protein: RREB1
Summary
InnateDB Protein IDBP-59368.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RREB1
Protein Name ras responsive element binding protein 1
Synonyms FINB; HNT; LZ321; RREB-1; Zep-1;
Species Homo sapiens
Ensembl Protein ENSP00000305560
InnateDB Gene IDBG-59362 (RREB1)
Protein Structure
UniProt Annotation
Function Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. {ECO:0000269PubMed:10390538, ECO:0000269PubMed:12482979, ECO:0000269PubMed:15067362, ECO:0000269PubMed:17550981, ECO:0000269PubMed:8816445, ECO:0000269PubMed:9305772}.
Subcellular Localization Nucleus speckle {ECO:0000269PubMed:15067362, ECO:0000269PubMed:17550981, ECO:0000269PubMed:9305772}.
Disease Associations
Tissue Specificity Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain. {ECO:0000269PubMed:8816445}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007265 Ras protein signal transduction
GO:0007275 multicellular organismal development
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92766
PhosphoSite PhosphoSite-Q92766
TrEMBL C9JU34
UniProt Splice Variant
Entrez Gene 6239
UniGene Hs.687210
RefSeq NP_001003698
HUGO HGNC:10449
OMIM 602209
CCDS CCDS34336
HPRD 03733
IMGT
EMBL AB019254 AB019351 AB019352 AF072825 AF072826 AL139095 AL355336 AL589644 BC042910 BC131599 CH471087 D49835 HM369360 HM369361 U26914
GenPept AAB19094 AAC25598 AAC26118 AAH42910 AAI31600 ADO14468 ADO14469 BAA23165 BAD32776 BAD32778 BAD32779 CAH73521 CAI14574 CAI16450 EAW55198 EAW55199 EAW55200

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca